Sphincter EMG and differential diagnosis of multiple system atrophy
Identifieur interne : 001A15 ( Main/Exploration ); précédent : 001A14; suivant : 001A16Sphincter EMG and differential diagnosis of multiple system atrophy
Auteurs : D. B. Vodušek [Slovénie]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-07.
English descriptors
Abstract
Multiple system atrophy (MSA) is a degenerative disease manifesting a combination of parkinsonism, cerebellar, pyramidal, and autonomic (including urinary, sexual, and anorectal) dysfunction. It is pathomorphologically defined, but lacks a definitive clinical diagnostic test. Sphincter electromyography (EMG), reflecting Onuf's nucleus degeneration, has been proposed as a helpful test; its value has been reevaluated by a critical review of the literature. In patients with probable MSA, abnormal sphincter EMG, as compared to control subjects, has been found in the majority of patients in all the different forms of the disease in most studies, including patients who, as yet, have no urological or anorectal problems. The prevalence of abnormalities in the early stages of MSA is as yet unclear. Patients with Parkinson's disease (PD) as a rule do not show severe sphincter EMG abnormalities in the early stage of the disease. Anal sphincter EMG abnormalities (abnormal spontaneous activity or motor unit potential changes three standard deviations above valid control data) distinguish MSA from PD in the first 5 years after the onset of symptoms and signs, and from pure autonomic failure, as well as from cerebellar ataxias, if other causes for sphincter denervation have been ruled out. With such criteria, the sensitivity of the method is, however, low. EMG does not distinguish MSA from progressive supranuclear palsy. Future studies should use standardized anal sphincter EMG to better compare results from different centers and precisely define the sensitivity and specificity of the method. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1121
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sphincter EMG and differential diagnosis of multiple system atrophy</title><author><name sortKey="Vodusek, D B" sort="Vodusek, D B" uniqKey="Vodusek D" first="D. B." last="Vodušek">D. B. Vodušek</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EFB8A1B55ADE79619D7D4F2F1A2A71E16A51D46D</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1002/mds.1121</idno><idno type="url">https://api.istex.fr/document/EFB8A1B55ADE79619D7D4F2F1A2A71E16A51D46D/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001967</idno><idno type="wicri:Area/Main/Curation">001716</idno><idno type="wicri:Area/Main/Exploration">001A15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Sphincter EMG and differential diagnosis of multiple system atrophy</title><author><name sortKey="Vodusek, D B" sort="Vodusek, D B" uniqKey="Vodusek D" first="D. B." last="Vodušek">D. B. Vodušek</name><affiliation wicri:level="1"><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-07">2001-07</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="600">600</biblScope><biblScope unit="page" to="607">607</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EFB8A1B55ADE79619D7D4F2F1A2A71E16A51D46D</idno><idno type="DOI">10.1002/mds.1121</idno><idno type="ArticleID">MDS1121</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>multiple system atrophy</term><term>progressive supranuclear palsy</term><term>sphincter EMG</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy (MSA) is a degenerative disease manifesting a combination of parkinsonism, cerebellar, pyramidal, and autonomic (including urinary, sexual, and anorectal) dysfunction. It is pathomorphologically defined, but lacks a definitive clinical diagnostic test. Sphincter electromyography (EMG), reflecting Onuf's nucleus degeneration, has been proposed as a helpful test; its value has been reevaluated by a critical review of the literature. In patients with probable MSA, abnormal sphincter EMG, as compared to control subjects, has been found in the majority of patients in all the different forms of the disease in most studies, including patients who, as yet, have no urological or anorectal problems. The prevalence of abnormalities in the early stages of MSA is as yet unclear. Patients with Parkinson's disease (PD) as a rule do not show severe sphincter EMG abnormalities in the early stage of the disease. Anal sphincter EMG abnormalities (abnormal spontaneous activity or motor unit potential changes three standard deviations above valid control data) distinguish MSA from PD in the first 5 years after the onset of symptoms and signs, and from pure autonomic failure, as well as from cerebellar ataxias, if other causes for sphincter denervation have been ruled out. With such criteria, the sensitivity of the method is, however, low. EMG does not distinguish MSA from progressive supranuclear palsy. Future studies should use standardized anal sphincter EMG to better compare results from different centers and precisely define the sensitivity and specificity of the method. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Slovénie</li></country></list><tree><country name="Slovénie"><noRegion><name sortKey="Vodusek, D B" sort="Vodusek, D B" uniqKey="Vodusek D" first="D. B." last="Vodušek">D. B. Vodušek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A15 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A15 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EFB8A1B55ADE79619D7D4F2F1A2A71E16A51D46D
|texte= Sphincter EMG and differential diagnosis of multiple system atrophy
}}
| This area was generated with Dilib version V0.6.23. |  |